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Sheth, N. R.
- Phytochemical Investigation and Immunomodulatory Activity of Lagenaria siceraria Fruits
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Journal of Natural Remedies, Vol 10, No 2 (2010), Pagination: 170-174Abstract
An attempt has been made to assess the immunomodulatory activity of methanolic extract of Lagenaria siceraria fruits at three dose levels ranging from 100-500 mg /kg body weight in rats using haemagglutination antibody titre, in vivo phagocytosis and cyclophosphamide-induced myelosuppression. Methanolic extract increased haemagglutination antibody titre and carbon clearance significantly. It also prevented myelosuppression in rats treated with immunosuppressive drug-cyclophosphamide. A significant increase in white blood cell count was observed in methanolic extract - treated rats as compared with cyclophosphamide treatment alone. Methanolic extract and its different fractions were also tested phytochemically. It is concluded that Lagenaria siceraria fruits possess immunomodulatory activity.Keywords
Myelosuppression, Immunomodulation, Lagenaria siceraria, Phytochemical ScreeningFull Text
- Optimization of Solvents and Processing Conditions for Crystallization of Aceclofenac
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Authors
Affiliations
1 Department of Pharmaceutics, B. K. Mody Govt. Pharmacy College, Rajkot-360003, IN
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot – 360005, IN
3 Department of Pharmaceutics, Matushree V. B. Manvar College of Pharmacy, Upleta-360440, IN
1 Department of Pharmaceutics, B. K. Mody Govt. Pharmacy College, Rajkot-360003, IN
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot – 360005, IN
3 Department of Pharmaceutics, Matushree V. B. Manvar College of Pharmacy, Upleta-360440, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 3 (2013), Pagination: 122-132Abstract
Background: Polymorphism is the phenomena where drug exists in more than one crystalline form. Though polymorphs are chemically identical, they exhibit different physicochemical properties like melting point, solubility, dissolution profile etc. which further affect the biological properties of drugs. The purpose of this work was to study the effect of solvents of different polarity and processing conditions on crystallization and physicochemical properties of Aceclofenac.
Methods: The crystals were prepared from different polarity of solvents and processing conditions like deep freezing, law temperature cooling, room temperature cooling etc. The melting point, solubility, dissolution profile, Fourier Transform Infra-Red, Differential Scanning Calorimetry, X-Ray Diffraction and Scanning Electron Microscopy studies were carried out to check for polymorphism in drug. Dissolution kinetic was also studied to compare the dissolution profiles of drug and its crystals.
Result: The result indicate that crystal obtained from different solvents and processing conditions exhibited different physicochemical properties. Though FT-IR and XRD gave an indication of difference in the spectra, but DSC proved absence of any polymorphic behavior in the crystals of aceclofenac.
Conclusion: It was concluded that the crystals with different properties can be obtained by changing solvent polarity and processing conditions.
Keywords
Aceclofenac, Polymorphism, Crystallization, Polarity, Processing Conditions.
- Pharmacognostical and Preliminary Phytochemical Screening of Erythrina indica Linn.
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Authors
Affiliations
1 Dept. of Pharmacognosy, N.R Vekariya Institute of Pharmacy and Research Centre, C.L College Campus, Junagadh-362001 (Gujarat), IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, College Road, Himmatnager, Gujarat, IN
3 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, IN
4 N.R Vekariya Institute of Pharmacy and Research Center, C.L College Campus, Bilkha Road, Junagadh–362001, Gujarat, IN
1 Dept. of Pharmacognosy, N.R Vekariya Institute of Pharmacy and Research Centre, C.L College Campus, Junagadh-362001 (Gujarat), IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, College Road, Himmatnager, Gujarat, IN
3 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, IN
4 N.R Vekariya Institute of Pharmacy and Research Center, C.L College Campus, Bilkha Road, Junagadh–362001, Gujarat, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 3 (2010), Pagination: 220-224Abstract
Erythrina indica Linn (Leguminosae), a genus of trees or shrubs, is widely distributed in tropical and subtropical regions of India .The barks are used traditionally as astringent, febrifuge and in leprosy and fever. Scientifically reported activities of Erythrina indica are Analgesic, Antibacterial activity, Anthelmintic Activity, Hypoglycaemic Activity and Diuretic activity. The present study involves Pharmacognosy and preliminary phytochemical investigations of the stem bark of Erythrina indica. This study consisted of the morphological and microscopical study of the plant; the phytochemical screening and testing for alkaloids, glycosides, tannins, steroids and flavonoids; TLC study and HPTLC fingerprinting. The parameters from the above were recorded with an objective of drawing an attention on the plant as well as a reference for further scientific investigations.Keywords
Erythrina indica, Flavanoids, Microscopical, Pharmacognosy.- Simultaneous Estimation of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride in Pharmaceutical Dosage Forms by RP-HPLC Method
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The calibration curves were linear in the concentration range of 4-24 μg/ml for Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride. The proposed method was validated and successfully applied to the estimation of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride in combined tablet dosage forms. Linearity was obtained in the concentration range of 4 to 24 μg/ml of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride with a correlation coefficient of 0.9963, 0.9992 and 0.9957 respectively. Detector consists of photodiode array detector; the reversed phase column used was RP-C18 (2.27 μm size, 250 mm, 4.6 mm i.d.) at ambient temperature. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride in routine analysis.
Authors
Chetan Ramolia
1,
Zarna Dedania
2,
Ronak Dedania
2,
N. R. Sheth
3,
G. Vidya Sagar
2,
Bhavna Patel
4,
K. K. Bhatt
5
Affiliations
1 CRO, Veeda, Ahmedabad, IN
2 Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, IN
3 Department of Pharmaceutical Sciences, Saurastra University, Rajkot, Gujarat, IN
4 CVM Institute for Degree Course in Pharmacy, New Vallabh Vidhyanagar, IN
5 Ipcowala Indukaka College of Pharmacy, Vallabh Vidhyanagar, IN
1 CRO, Veeda, Ahmedabad, IN
2 Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, IN
3 Department of Pharmaceutical Sciences, Saurastra University, Rajkot, Gujarat, IN
4 CVM Institute for Degree Course in Pharmacy, New Vallabh Vidhyanagar, IN
5 Ipcowala Indukaka College of Pharmacy, Vallabh Vidhyanagar, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 83-86Abstract
A simple, specific, accurate and stability indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of and Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride in tablet dosage forms. Detector consists of photodiode array detector; the reversed phase column used was RP-C18 (2.27 μm size, 250 mm´4.6 mm i.d.) at ambient temperature, in isocratic mode, with mobile phase containing Methnol: Acetonitrile: Phosphate Buffer, pH 5.39 (20: 40: 40% v/v/v) adjusted to pH 5.39 using ortho phosphoric acid was used. The flow rate was 1.0 ml/min and effluents were monitored at 238 nm. The retention times of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride were 3.69 min, 8.18 min and 12.5 min respectively.The calibration curves were linear in the concentration range of 4-24 μg/ml for Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride. The proposed method was validated and successfully applied to the estimation of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride in combined tablet dosage forms. Linearity was obtained in the concentration range of 4 to 24 μg/ml of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride with a correlation coefficient of 0.9963, 0.9992 and 0.9957 respectively. Detector consists of photodiode array detector; the reversed phase column used was RP-C18 (2.27 μm size, 250 mm, 4.6 mm i.d.) at ambient temperature. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride in routine analysis.
Keywords
Metformin Hydrochloride, Rosiglitazone Maleate and Glimepiride, RP-HPLC.- RP-HPLC Method for Simultaneous Estimation of Omeprazole and Ondansetron in Combined Dosage Forms
Abstract Views :182 |
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Authors
Zarna Dedania
1,
Ronak Dedania
1,
Vaishali Karkhanis
2,
G. Vidya Sagar
1,
Meeta Baldania
1,
N. R. Sheth
3
Affiliations
1 Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, Gujarat, IN
2 A.R. College of Pharmacy, Vallabh, Vidhyanagar, Gujarat, IN
3 Department of Pharmaeutical Sciences, Saurastra University, Rajkot, Gujarat, IN
1 Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, Gujarat, IN
2 A.R. College of Pharmacy, Vallabh, Vidhyanagar, Gujarat, IN
3 Department of Pharmaeutical Sciences, Saurastra University, Rajkot, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 2 (2009), Pagination: 108-111Abstract
A RP-HPLC method is developed for simultaneous estimation of omeprazole and ondansetron in combined tablet dosage form. Omeprazole is a proton pump inhibitor and in the treatment of gastro-oesophageal reflux disease (GERD), peptic ulcer and Zollinger-Ellison syndrome. Ondansetron is used as selective 5-HT3 receptor antagonist and used in the management of nausea and vomiting induced by cytotoxic chemotherapy and radio therapy and also post operative nausea and vomiting. The mobile phase used was a combination of Methanol: Acetonitrile (90:10). The detection of the combined dosage form was carried out at 218 nm and a flow rate employed was 0.5 ml/min. The retention time for omeprazole and ondansetron was found to be 5.39 and 11.08 min respectively. Linearity was obtained in the concentration range of 4 to 20 μg/ml of omeprazole and 4 to20 μg/ml of ondansetron with a correlation coefficient of 0.997 and 0.9967. Detector consists of photodiode array detector; the reversed phase column used was RP-C18 (2.27μm size, 250 mm´4.6 mm i.d.) at ambient temperature. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of ondansetron and omeprazole in routine analysis.Keywords
Simultaneous Estimation, RP-HPLC, Omeprazole, Ondansetron.- Hepatoprotective and Anti-Inflammatory Activities of Hydroalcoholic Extract of Bark of Erythrina Indica
Abstract Views :430 |
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Authors
Affiliations
1 Department of Pharmacognosy, Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, IN
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, IN
3 Gujarat Technological University, Ahmedabad, Gujarat, IN
4 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar, Gujarat, IN
1 Department of Pharmacognosy, Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, IN
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, IN
3 Gujarat Technological University, Ahmedabad, Gujarat, IN
4 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar, Gujarat, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 4 (2017), Pagination: 189-194Abstract
Background: Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver toxicity and inflammation.
Aim: This present work was done to investigate the Hepatoprotective and Anti-inflammatory activities of Hydroalcoholic extract of Bark of Erythrina indica .
Materials and Methods: Drugs like Silymarin, Carbon tetrachloride, Liquid paraffin, carrageenan, Aspirin were used. For Hepatoprotective activity SGOT, SGPT, ALKP, Total cholesterol, Total bilirubin, Albumin, Total protein Estimation kit and for anti-inflammatory activity carrageenan-induced paw oedema method were used.
Result and discussion: The hepatoprotective activity of the Hydroalcoholic extract was assessed in CCl4 induced hepatotoxic Rats. The extract of plant (300mg/kg and 500mg/kg, orally) was given for 6 days, daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) was given at 6th day after dosing of plant extract. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, Bilirubin, Cholesterol, Total Protein and Albumin were tested in both CCl4 treated and untreated groups. CCl4 has enhanced the SGOT, SGPT, ALKP and Bilirubin in serum, while Total protein and Albumin were decreased. The study was also supported by histopathology of liver sections. Treatment of Hydroalcoholic extract of Bark of Erythrina indica has brought back the altered levels of biochemical markers to near about normal levels in the dose dependent manner. Antiinflammatory activity was done in rats at a dose 300 and 500 mg/kg in carrageenan-induced paw oedema method. Hydroalcoholic extract of Erythrina indica bark significantly reduced the migration of neutrophils and monocytes. Results of in vivo activity lead to the conclusion that the hydroalcoholic extract of Erythrina indica bark showed predominantly significant activity in dose dependent manner, which is comparable to the standard drug Aspirin. The present study reveals that the Hydroalcoholic extract of Bark of Erythrina indica could afford a significant Hepatoprotective and Anti-inflammatory activity.
Keywords
Erythrina indica, CCl4, SGOT, SGPT, ALKP, Aspirin, Carrageenan.References
- Meyer S.A., Kulkarni A.P., hepatotoxicity. In: Hodgson E., Smart R.C., Editors. Introduction to biochemical toxicology. New York: John Wiley and Sons .2001; 487-490.
- Mascolo N., Sharma R., Jain S.C., Capasso F., J Ethnopharmacol. 1994; 22: 211.
- Mossa J.S., Tariq M., Mohsin A., Aqeel A.M., al-Yahya M.A., alSaid M.S., Am J Chin Med.1991; 19: 223.
- Handa. S.S., Sharma. A., Chakraborty. K.K., Natural products and plants as liver protecting drugs; Fitoterapia.. 1989; 57: 307-351.
- Slater T.F., Sawyer B.C., The Stimulatory effect of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver functions in vitro. Inhibitor effects of free radical scavengers and other agents. Biochem J. 1971; 123: 823-828.
- De Pomerai D. I., Pritchard D. J., Clayton R. M., Biochemical and immunological studies of Lentoid formation in cultures of embryonic chick neural retina and day-old chick lens epithelium. Dev Biol. 1977; 60: 416-427.
- Recknagel R.O., Glende E.A., Dolak J.A., Waller R.L., Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther. 1989; 43: 139-154.
- Venkateswaran S., Pari L., Viswanathan P., Menon V.P., Protective effect of herbal formulation against erythromycin estolate- induce hepatotoxicity in rats. J. Ethnopharmacol. 1997; 57: 161-167.
- Latha U., Rajesh M.G., Latha M.S., Hepatoprotective effect of an Ayurvedic medicine, Ind. Drugs. 1999; 36: 470-473.
- Mithra S.K., Seshadri S.J., Venkataranganna M.V., Gopumadhavan S., Venkatesh Udupa U., Sarma D.N.K., Effect of HD-03-a herbal formulation in Galactosamine induced hepatopathy in rats. Indian J. Physiol. Pharmacol. 2000; 44: 8286.
- Dhuley G.P., Naik S.R., Protective effect if Rhinax, herbal formulation against CCL4 induced liver injury and survival in rats. J. Ethnopharmacol. 1997; 56: 159-164.
- Freidman. S.E., Grendell. J.H., McQuaid. K.R., Current diagnosis and treatment in gastroenterology. New York: Lang Medical Books/McGraw-Hill. 2003; 664-679.
- Mukherjee P.K., Quality Control of Herbal Drugs— An Approach to Evaluation of Botanicals. New Delhi: Business Horizons. 2002.
- Maity T.K., Mandal S.C., Mukherjee P.K., Saha K., Saha B.P., Das J., Pal M., Evaluation of Hepatoprotective potential of Cassia tora leaf extract. Nat Prod Sci. 1997; 3: 122–126.
- Mitchell R. N. and R.S. Cotran, In: Robinsons Basic Pathology, 7th Edn., Harcourt (India) Pvt Ltd., New Delhi. 2000; 33.
- Haque R., Mohammad S., Achinto S., Alimuzzaman M.D., Analgesic Activity of Methanolic Extract of the Leaf of Erythrina variegate. J. Pharm. Sci. 2006; 5(1-2): 77-79.
- Ghani A., Medicinal Plants of Bangladesh with chemical constituents and uses. published by Asiatic Society of Bangladesh. 2nd edition, 222-223.
- Kumar G., Banu G.S., Pappa P.V., Sundrarajan M., and Pandian M.R., Hepatoprotective activity of Trainthema portulacastrum L. against paracetamol and thioaacetamide intoxication in albino rats. J.Ethnopharmacol. 2004; 92(1): 37-40.
- Kamat V.S., Chuo F.Y., Kubo I., Nakanishi K.,. Anti-microbial agents from an East-African medicinal plant, Erythrina abyssinica. Heterocycles 1981; 15: 1163–1170.
- Fomum Z.T., Ayafor J.F., Erythrina studies: Part 2. Structures of the novel prenylated antibacterial flavanones, sigmoidins A–C from Erythrina sigmoidea. J. Chem. Soc., Perkin Trans. 1986; 1: 33–37.
- Fomum Z.T., Ayafor J.F., Mbafor J.T., Erythrina studies: Part 1. Novel antibacterial flavanones from Erythrina sigmoidea. Tetrahedron Lett. 1983; 24: 4127– 4130.
- Fomum Z.T., Nkenfack A.E., Wandji J., Erythrina studies: Part 15. Pharmacological screening of three esters isolated from Erythrina plants. Ann. Fac. Sci. Chim. 1988;2:79– 104.
- Wandji J., Fomum Z.T., Tillequin F., Seguin E., Koch M., Erythrina studies: Part 24. Two isoflavones from Erythrina senegalensis. Phytochemistry. 1994; 35: 245– 248.
- Kirtikar K.R., Basu B.D., Indian medicinal plants, International Book Distributors, Dehradun, 2nd Ed. 1991; Vol-1, 781-784.
- Khalid H. J., Anwar H. G., Evaluation of the protective potential of Artemisia maritime extract on acetaminophen and CCl4 induced liver damage. Journal of Ethnopharmacology. 1995; 47: 43-47.
- Bahar A., Tanveer A., Shah A.K.., Hepatoprotective activity of Luffa echinata fruits. Journal of Ethnopharmacology. 2001; 76: 187–189.
- Porchezhian E., Ansari S.H., Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats. Phytomedicine. 2005; 12: 62–64.
- Rao K.S., Mishra S.H., Anti-inflammatory and Hepatoprotective activities of fruits of Moringa pterygosperma Gaertn. Ind. J. Nat. Prod. 1998; 3: 14.
- Rao K.S., Mishra S.H., Anti-inflammatory and Hepatoprotective activities of fruits of Moringa pterygosperma Gaertn. Ind. J. Nat. Prod. 1998; 3: 14.
- Fakurazi S., Hairuszah I., Nanthini U., Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food and Chemical Toxicology. 2008; 46: 2611– 2615.
- Vishnukanta, Rana A.C., Analgesic and Anti-Inflammatory Activity of Hydroalcoholic Extract of Leaves of Plumbago zeylanica. Phcog Mag. 2008; 4.
- Vendruscolo A., Takaki I., Amado L.E.B., Dantas J. A., Amado C.A.B., Suman R. K. N., Anti-inflammatory and antinociceptive activities of Zingiber officinale Roscoe essential oil in experimental animal models. Ind. J. Pharmacol. 2006; 38(1): 58-59.
- Balian S., Ahmad S., Zafar R., Anti-inflammatory activity of leaf and leaf callus of Silybum marianum (L.) Gaertn. In albino rats. Ind. J. Pharmacol. 2006; 38(3): 213-214.
- Sutradhar R.K., Rahman A. K. M. M., Ahmad M.U., Datta B.K., Bachar S.C., Saha A., Anti-inflammatory activity of Sida cordifolia Linn. Ind. J. Pharmacol. 2006; 38(3): 207-208.
- Ahmet C.O., Ufuk M., Hatice O., Nureddin C., Remzi E.,Hanefi O., Anti-inflammatory and Hepatoprotective Activities of Trigonella foenum-graecum L. Pharmacologyonline. 2008; 2: 126-132.
- Ratheesh M., Helen A., Anti-inflammatory activity of Ruta graveolens Linn on carrageenan induced paw edema in wistar male rats. African Journal of Biotechnology. 2007; 6 (10): 1209-1211.